2021

*Lohning, A., Kidachi, Y., Kamiie, K., Sasaki, K., Ryoyama, K., Yamaguchi, H. 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC) from Wasabia japonica alleviates inflammatory bowel disease (IBD) by potential inhibition of glycogen synthase kinase 3 beta (GSK-3β).

Eur. J. Med. Chem., 216, 113250 (2021)


2019

*Beck, K.R., Inderbinen, S.G., Kanagaratnam, S., Kratschmar, D.V., Jetten, A.M., Yamaguchi, H., Odermatt, A. 11β-Hydroxysteroid dehydrogenases control access of 7β,27-dihydroxycholesterol to retinoid-related orphan receptor γ.

J. Lipid Res., 60, 1535-1546 (2019)

*Beck, K.R., Kanagaratnam, S., Kratschmar, D.V., Birk, J., Yamaguchi, H., Sailer, A.W., Seuwen, K., Odermatt, A. Enzymatic interconversion of the oxysterols 7β,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2.

J. Steroid Biochem. Mol. Biol., 190, 19-28 (2019) 

*Zinchenko, A., Hiramatsu, H., Yamaguchi, H., Kubo, K., Murata, S., Kanbe, T., Hazemoto, N., Yoshikawa, K., Akitaya, T. Amino acid sequence of oligopeptide causes marked difference in DNA compaction and transcription.

Biophys. J., 116, 1836-1844 (2019) 


2017

*Beck, K.R., Bachler, M., Vuorinen, A., Wagner, S., Akram, M., Griesser, U., Temml, V., Klusonova, P., Yamaguchi, H., Schuster, D., Odermatt, A. Inhibition of 11β-hydroxysteroid dehydrogenese 2 by the fungicides itraconazole and posaconazole.

Biochem. Pharmacol., 130, 93-103 (2017) 


2016

*Murumkar, P.R., Shinde, A.C., Sharma, M.K., Yamaguchi, H., Miniyar, P.B., Yadav, M.R. Development of a credible 3D-QSAR CoMSIA model and docking studies for a series of triazoles and tetrazoles containing 11β-HSD1 inhibitors.

SAR QSAR Environ. Res., 27, 265-292 (2016) 


2015

*Kamiie, K., Noshita, T., Kidachi, Y., Yamaguchi, H. Structural insight into the homology modeled human N-acetyl-alpha-neuraminidase 3 (NEU3): Part2.

Int. J. Comput. Bioinfo. In Silico Model., 4, 753-760 (2015)


2014

*Yamaguchi, H. Structural insight into the homology modeled human N-acetyl-alpha-neuraminidase 3 (NEU3).

Int. J. Comput. Bioinfo. In Silico Model., 3, 525-530 (2014)

*Yamaguchi, H. Homology modeling and structural analysis of human N-acetyl-alpha-neuraminidase 3 (NEU3).

Int. J. Comput. Bioinfo. In Silico Model., 3, 473-478 (2014) 

*Yamaguchi, H., Kamiie, K., Kidachi, Y., Noshita, T., Umetsu, H., Fuke, Y., Ryoyama, K. Structural basis for the interaction of 6-(methylsulfinyl)hexyl isothiocyanate with inducible nitric oxide synthase.

Int. J. Comput. Bioinfo. In Silico Model., 3, 426-432 (2014)

*Yamaguchi, H., Kamiie, K., Kidachi, Y., Noshita, T., Umetsu, H., Fuke, Y., Ryoyama, K. Structural insight into the ligand-receptor interaction between 6-(methylsulfinyl)hexyl isothiocyanate and multidrug resistance-associated protein 1 nucleotide-binding domain 1.

Int. J. Comput. Bioinfo. In Silico Model., 3, 310-314 (2014) 

*Yamaguchi, H., Kamiie, K., Kidachi, Y., Noshita, T., Umetsu, H., Fuke, Y., Ryoyama, K. Intracellular accumulation of structurally varied isothiocyanates correlates with inhibition of nitric oxide production in proinflammatory stimuli-activated tumorigenic macrophage-like cells.

Bioorg. & Med. Chem., 22, 440-446 (2014)

2013

*Yamaguchi, H., Kamiie, K., Kidachi, Y., Noshita, T., Umetsu, H., Fuke, Y., Ryoyama, K. Prediction of the possible inhibitory effect of 6-(methylsulfinyl)hexyl isothiocyanate (6MITC) and its analogs on P-glycoprotein (P-gp) by in silico analysis of their interaction energies.

Int. J. Comput. Bioinfo. In Silico Model., 2, 206-212 (2013) 

*Yamaguchi, H., Kidachi, Y., Kamiie, K., Noshita, T., Umetsu, H., Fuke, Y., Ryoyama, K. Utilization of 6-(methylsulfinyl)hexyl isothiocyanate for sensitization of tumor cells to antitumor agents in combination therapies.

Biochem. Pharmacol., 86, 458-468 (2013)

2012

*Yamaguchi, H., Kidachi, Y., Kamiie, K., Noshita, T., Umetsu, H. Structural insight into the ligand-receptor interaction between glycyrrhetinic acid (GA) and the high-mobility group protein B1 (HMGB1)-DNA complex.

Bioinformation, 8, 1147-1153 (2012)

*Yamaguchi, H., Kidachi, Y., Kamiie, K., Noshita, T., Umetsu, H. Homology modeling and structural analysis of human P-glycoprotein.

Bioinformation, 8, 1066-1074 (2012)

*Yamaguchi, H., Akitaya, T., Kidachi, Y., Kamiie, K., Umetsu, H. Homology modeling and structural analysis of human γ-glutamylcysteine ligase catalytic subunit for antitumor drug development.

J. Biophys. Chem., 3, 238-248 (2012) 

*Yamaguchi, H., Akitaya, T., Yu, T., Kidachi, Y., Kamiie, K., Noshita, T., Umetsu, H., Ryoyama, K. Molecular docking and structural analysis of cofactor-protein interactions between NAD+ and 11β-hydroxysteroid dehydrogenase type 2.

J. Mol. Model., 18, 1037-1048 (2012)

2011

*Yamaguchi, H., Akitaya, T., Kidachi, Y., Kamiie, K., Noshita, T., Umetsu, H., Ryoyama, K. Mouse 11β-hydroxysteroid dehydrogenase type 2 for human application: Homology modeling, structural analysis and ligand-receptor interaction.

Cancer Informatics, 10, 287-295 (2011)

*Yamaguchi, H., Yu, T., Noshita, T., Kidachi, Y., Kamiie, K., Yoshida, K., Akitaya, T., Umetsu, H., Ryoyama, K. Ligand-receptor interaction between triterpenoids and the 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) enzyme predicts their toxic effects against tumorigenic r/m HM-SFME-1 cells.

J. Biol. Chem., 286, 36888-36897 (2011)

*Yamaguchi, H., Yu, T., Kidachi, Y., Akitaya, T., Yoshida, K., Kamiie, K., Noshita, T., Umetsu, H., Ryoyama, K. Selective toxicity of glycyrrhetinic acid against tumorigenic r/m HM-SFME-1 cells is potentially attributed to downregulation of glutathione.

Biochimie, 93, 1172-1178 (2011)

*Yamaguchi, H., Akitaya, T., Yu, T., Kidachi, Y., Kamiie, K., Noshita, T., Umetsu, H., Ryoyama, K. Homology modeling and structural analysis of 11β-hydroxysteroid dehydrogenase type 2.

Eur. J. Med. Chem., 46, 1325-1330 (2011)

2010

*Yamaguchi, H., Noshita, T., Yu, T., Kidachi, Y., Kamiie, K., Umetsu, H., Ryoyama, K. Novel effects of glycyrrhetinic acid on the central nervous system tumorigenic progenitor cells: Induction of actin disruption and tumor cell-selective toxicity.

Eur. J. Med. Chem., 45, 2943-2948 (2010)

*Yu, T., Yamaguchi, H., Noshita, T., Kidachi, Y., Umetsu, H., Ryoyama, K. Selective cytotoxicity of glycyrrhetinic acid against tumorigenic r/m HM-SFME-1 cells: Potential involvement of H-Ras downregulation.

Toxicol. Lett., 192, 425-430 (2010)

*Yamaguchi, H., Kidachi, Y., Kamiie, K., Noshita, T., Umetsu, H., Ryoyama, K. Glycyrrhetinic acid induces anoikis-like death and cytoskeletal disruption in the central nervous system tumorigenic cells.

Biol. Pharm. Bull., 33, 321-324 (2010)

2009

*Noshita, T., Kidachi, Y., Funayama, H., Kiyoya, H., Yamaguchi, H., Ryoyama, K. Anti-nitric oxide production activity of isothiocyanates correlates with their polar surface area rather than their lipophilicity.

Eur. J. Med. Chem., 44, 4931-4936 (2009)

*Kidachi, Y., Noshita, T., Yamaguchi, H., Umetsu, H., Fuke, Y., Ryoyama, K. Augmenting activity of 6-(methylsulfinyl)hexyl isothiocyanate on cellular glutathione levels is less sensitive to thiol compounds than its cytotoxic activity.

Biosci. Biotechnol. Biochem., 73, 1419-1421 (2009)

2008

*Yamaguchi, H., Noshita, T., Kidachi, Y., Umetsu, H., Komiyama, K., Funayama, S., Ryoyama, K. Isolation of ursolic acid from apple peels and its efficacy as a potent antitumor agent.

J. Health Sci., 54, 654-660 (2008)

*Yamaguchi, H., Kidachi, Y., Umetsu, H., Ryoyama, K. Hypoxia enhances gene expression of inducible nitric oxide synthase and matrix metalloproteinase-9 in ras/myc-transformed serum-free mouse embryo cells under simulated inflammatory and infectious conditions.

Cell Biology International, 32, 940-949 (2008)

*Yamaguchi, H., Noshita, T., Kidachi, Y., Umetsu, H., Fuke, Y., Ryoyama, K. Differentiation of serum-free mouse embryo cells into an astrocytic lineage is regulated by the asymmetric production of early neural, neuronal and glial markers.

Biol. Pharm. Bull., 31, 1008-1012 (2008)

*Yamaguchi, H., Kidachi, Y., Umetsu, H., Ryoyama, K. Detection of 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC) and its conjugate with N-acetyl-L-cysteine (NAC) by high performance liquid chromatograpy - atmospheric pressure chemical ionization mass spectrometry (HPLC-MS/APCI).

Chem. Pharm. Bull., 56, 715-719 (2008)

*Yamaguchi, H., Kidachi, Y., Umetsu, H., Ryoyama, K. L-NAME inhibits tumor cell progression and pulmonary metastasis of r/m HM-SFME-1 cells by decreasing NO release from tumor cells and TNF-α release from macrophages.

Mol. Cell. Biochem., 312, 103-112 (2008)

2007

*Yamaguchi, H., Kidachi, Y., Umetsu, H., Ryoyama, K. Ras/myc-transformed serum-free mouse embryo cells under simulated inflammatory and infectious conditions increase levels of nitric oxide and matrix metalloproteinase-9 without a direct association between them.

Mol. Cell. Biochem., 306, 43-51 (2007)

*Kidachi, Y., Yamaguchi, H., Umetsu, H., Ryoyama, K. Interferon-gamma and lipopolysaccharide stimulation increases matrix metalloproteinase-9 expression and enhances invasion activity in ras/myc-transformed serum-free mouse embryo cells.

Cell Biology International, 31, 1511-1517 (2007)

*Yamaguchi, H., Zhu, J., Yu, T., Sasaki, K., Umetsu, H., Kidachi, Y., Ryoyama, K. Serum-free mouse embryo cells generate a self-sustaining feedback loop for an astrocyte marker protein and respond to cytokines and bisphenol A in accordance with the subtle difference in their differentiation state.

Cell Biology International, 31, 638-644 (2007)